Unravelling metabolic dependencies
نویسندگان
چکیده
منابع مشابه
Metabolic Dependencies in RAS-Driven Cancers.
The ability to inhibit the RAS oncogene has been the holy grail of oncology because of the critical role of this gene in a multitude of tumor types. In addition, RAS-mutant tumors are among the most aggressive and refractory to treatment. Although directly targeting the RAS oncogene has proven challenging, an alternative approach for treating RAS-driven cancers is to inhibit critical downstream...
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Adipose tissue composed of adipocytes, fibroblasts, immune cells, and various other cell types, once known as passive reservoir is now considered an endocrine organ secreting bioactive molecules including hormones now termed adipokines with various known and unknown endocrine functions in addition to regulating fat mass and nutrient homeostasis. Due to the dramatic rise in obesity and its metab...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2012
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3273